Article
The role of acetylator genotype on hepatic and extrahepatic acetylation, deacetylation, and sulfation of 2-aminofluorene, 2-acetylaminofluorene, and N-hydroxy-2-acetylaminofluorene in the inbred hamster.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Hein D W, Kirlin W G, Ogolla F, Trinidad A, Thompson L K, Ferguson R J
Abstract excerpt
In vitro rates of acetylation, deacetylation, and sulfation were measured with carcinogenic arylamine, arylamide, and arylhydroxamic acid substrates using enzyme preparations derived from inbred hamster tissues of known acetylator genotype. Homozygous rapid acetylators (Bio. 87.20), heterozygous...
Topics
- 2-Acetylaminofluorene
- Acetylation
- Acetyltransferases
- Amidohydrolases
- Animals
- Cricetinae
- Fluorenes
- Genotype
- Hydroxyacetylaminofluorene
- Isoenzymes
- Liver
- Male
- Mesocricetus
- Paraoxon
- Sulfurtransferases