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Article

N-acetylation of the heterocyclic amine batracylin by human liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 1999

Stevens G J, Payton M, Sim E, McQueen C A

Abstract excerpt

Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10 H)-one; BAT) is a heterocyclic amine that exhibits antitumor activity in a number of in vivo and in vitro models. The acetyl product has been implicated in BAT toxicity in animals, cells, and bacteria. The ability of human N-acetyltransferase (NAT) to form this product was investigated. Nine human liver samples were analyzed for NAT1 and NAT2 genotypes. Seven of...

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Share to 4-Aminobenzoic Acid
Share to Acetylation
Share to Arylamine N-Acetyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to In Vitro Techniques

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Source

Identifiers

PMID: 10460792

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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