Article
Genetic control of acetyl coenzyme A-dependent arylamine N-acetyltransferase, hydrazine N-acetyltransferase, and N-hydroxy-arylamine O-acetyltransferase enzymes in C57BL/6J, A/J, AC57F1, and the rapid and slow acetylator A.B6 and B6.A congenic inbred mouse.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Hein D W, Trinidad A, Yerokun T, Ferguson R J, Kirlin W G, Weber W W
Abstract excerpt
Acetyl coenzyme A-dependent N-acetyltransferase and O-acetyltransferase activities were examined in liver cytosols derived from homozygous rapid acetylator C57BL/6J and A.B6 congenic inbred mouse strains, from homozygous slow acetylator A/J and B6.A congenic inbred mouse strains, and from the (C57BL/6J x A/J)F1 heterozygous acetylator hybrid mouse strain. Acetylator genotype-dependent N-acetyltransferase activity...
Topics
- Acetyl-CoA C-Acetyltransferase
- Acetylation
- Acetyltransferases
- Acyltransferases
- Animals
- Arylamine N-Acetyltransferase
- Chromatography, Ion Exchange
- Cytosol
- Genotype