Article
Distribution of 2-aminofluorene and p-aminobenzoic acid N-acetyltransferase activity in tissues of C57BL/6J rapid and B6.A-NatS slow acetylator congenic mice.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Chung J G, Levy G N, Weber W W
Abstract excerpt
The distribution of N-acetyltransferase (NAT) activity in 35 tissues of inbred rapid acetylator C57BL/6J and slow acetylator congenic B6.A-NatS mice was determined by incubation of tissue cytosols with 2-aminofluorene or p-aminobenzoic acid followed by HPLC assay. Tissues examined included the ga...
Topics
- 4-Aminobenzoic Acid
- Acetylation
- Alleles
- Animals
- Arylamine N-Acetyltransferase
- Cytosol
- Digestive System
- Electrophoresis
- Fluorenes
- Lymphoid Tissue
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Seminal Vesicles
- Tissue Distribution