Human N-acetylation of benzidine: role of NAT1 and NAT2.

Article

Human N-acetylation of benzidine: role of NAT1 and NAT2.

Cancer research - 1 Sept 1996

Zenser T V, Lakshmi V M, Rustan T D, Doll M A, Deitz A C, Davis B B, Hein D W

Abstract excerpt

These studies were designed to assess metabolism of benzidine and N-acetylbenzidine by N-acetyltransferase (NAT) NAT1 and NAT2. Metabolism was assessed using human recombinant NAT1 and NAT2 and human liver slices. For benzidine and N-acetylbenzidine, Km and Vmax values were higher for NAT1 than f...

Topics

Acetylation
Arylamine N-Acetyltransferase
Base Sequence
Benzidines
Female
Genotype
Humans
Isoenzymes
Kinetics
Liver
Male
Middle Aged
Molecular Sequence Data
Phenotype
Recombinant Proteins

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