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Article

Human N-acetylation of benzidine: role of NAT1 and NAT2.

Cancer research - 1 Sept 1996

Zenser T V, Lakshmi V M, Rustan T D, Doll M A, Deitz A C, Davis B B, Hein D W

Abstract excerpt

These studies were designed to assess metabolism of benzidine and N-acetylbenzidine by N-acetyltransferase (NAT) NAT1 and NAT2. Metabolism was assessed using human recombinant NAT1 and NAT2 and human liver slices. For benzidine and N-acetylbenzidine, Km and Vmax values were higher for NAT1 than for NAT2. The clearance ratios (NAT1/NAT2) for benzidine and N-acetylbenzidine were 54 and 535, respectively, suggesting...

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Source

Identifiers

PMID: 8752161

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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