Article
Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.
Journal of virology - 1 Aug 1995
Desai-Yajnik V, Hadzic E, Modlinger P, Malhotra S, Gechlik G, Samuels H H
Abstract excerpt
Thyroid hormone (T3) receptor (T3R) regulates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) by binding to and activating thyroid hormone response elements (TREs) embedded within the viral NF-kappa B and Sp1 motifs. The TREs within the NF-kappa B sites are necessary for activation by T3 in the absence of Tat, while those in the Sp1 motifs function as TREs only when Tat is expressed,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
