Article
Defects in sensory organ morphogenesis and generation of cochlear hair cells in Gata3-deficient mouse embryos.
Hearing research - 1 Jan 2012
Haugas Maarja, Lilleväli Kersti, Salminen Marjo
Abstract excerpt
The development of the inner ear sensory epithelia involves a complex network of transcription factors and signaling pathways and the whole process is not yet entirely understood. GATA3 is a DNA-binding factor that is necessary for otic morphogenesis and without GATA3 variable defects have been observed already at early stages in mouse embryos. In the less severe phenotypes, one small oval shaped vesicle is...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Calcium-Binding Proteins
- Cell Differentiation
- Cochlea
- Embryonic Stem Cells
- Epithelial Cells
- GATA3 Transcription Factor
- Gene Expression Regulation, Developmental
- Genotype
- Gestational Age
- Hair Cells, Auditory
- Homeodomain Proteins