Article
BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice.
Scientific reports - 1 Jan 2012
Fukui H, Wong H T, Beyer L A, Case B G, Swiderski D L, Di Polo A, Ryan A F, Raphael Y
Abstract excerpt
Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a procedure that requires survival of the auditory nerve. Mouse mutations that serve as models for genetic deafness can be utilized for developing and enhancing therapies for hereditary deafness. A mouse with Pou4f3 loss of function has no hair cells and a...
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