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Article

Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer.

The American journal of pathology - 1 Jul 1995

Mirchandani D, Zheng J, Miller G J, Ghosh A K, Shibata D K, Cote R J, Roy-Burman P

Abstract excerpt

Prostatic carcinoma from 65 patients have been examined for the occurrence of point mutations in the p53 tumor suppressor gene locus within the region of exons 5 to 8. Overall, only a small fraction of tumors (12.3%) was found to contain p53 mutations. No significant correlation was detected betw...

Topics

Adenocarcinoma
Alleles
Base Sequence
DNA Primers
DNA, Neoplasm
Exons
Genes, p53
Genetic Heterogeneity
Humans
Immunoenzyme Techniques
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Prostatic Neoplasms

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 7604888
PMCID: PMC1869872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7604888-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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