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Article

Precise microdissection of human prostate cancers reveals genotypic heterogeneity.

Cancer research - 1 Jan 1998

Macintosh C A, Stower M, Reid N, Maitland N J

Abstract excerpt

To determine the incidence of genetic heterogeneity in primary prostate cancer, we have microdissected 125 tumor and mesenchymal foci from 18 patient biopsies and analyzed the DNA for loss of heterozygosity using PCR microsatellite markers. In 100% of patients with genetic lesions on chromosome 8p, there was evidence for intratumoral genetic heterogeneity. There was also a low but significant incidence of loss of...

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PMID: 9426051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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