Precise microdissection of human prostate cancers reveals genotypic heterogeneity.

Article

Precise microdissection of human prostate cancers reveals genotypic heterogeneity.

Cancer research - 1 Jan 1998

Macintosh C A, Stower M, Reid N, Maitland N J

Abstract excerpt

To determine the incidence of genetic heterogeneity in primary prostate cancer, we have microdissected 125 tumor and mesenchymal foci from 18 patient biopsies and analyzed the DNA for loss of heterozygosity using PCR microsatellite markers. In 100% of patients with genetic lesions on chromosome 8...

Topics

Chromosomes, Human, Pair 8
Dissection
Genetic Markers
Genotype
Humans
Loss of Heterozygosity
Male
Polymerase Chain Reaction
Prostatic Neoplasms

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