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Article

Molecular heterogeneity in prostate cancer: can TP53 mutation unravel tumorigenesis?

Molecular medicine today - 1 Nov 1997

Roy-Burman P, Zheng J, Miller G J

Abstract excerpt

While prostate cancer is the most common malignant visceral neoplasm of men, its etiology remains largely unknown and its clinical course unpredictable. Molecular genetics of prostate cancer has become a fruitful area of investigation and might provide clues to understanding these phenomena. Mutation of the TP53 tumor suppressor gene (encoding the p53 protein) has been commonly reported as a critical event in...

Topics

Disease Progression
Genetic Heterogeneity
Humans
Male
Mutation
Polymorphism, Single-Stranded Conformational
Prognosis
Prostate
Prostatic Neoplasms
Stem Cells
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9430782
DOI: 10.1016/S1357-4310(97)01126-X

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