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Article

Interplay of TBP inhibitors in global transcriptional control.

Molecular cell - 1 Oct 2002

Chitikila Carmelata, Huisinga Kathryn L, Irvin Jordan D, Basehoar Andrew D, Pugh B Franklin

Abstract excerpt

The TATA binding protein (TBP) is required for the expression of nearly all genes and is highly regulated both positively and negatively. Here, we use DNA microarrays to explore the genome-wide interplay of several TBP-interacting inhibitors in the yeast Saccharomyces cerevisiae. Our findings suggest the following: The NC2 inhibitor turns down, but not off, highly active genes. Autoinhibition of TBP through...

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Source

Identifiers

PMID: 12419230
DOI: 10.1016/s1097-2765(02)00683-4

Genes

TBP
TAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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