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Article

Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP).

Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002

Cang Yong, Prelich Gregory

Abstract excerpt

Negative cofactor 2 (NC2) is an evolutionarily conserved transcriptional regulator that was originally identified as an inhibitor of basal transcription. Its inhibitory mechanism has been extensively characterized; NC2 binds to the TATA-binding protein (TBP), blocking the recruitment of TFIIA and TFIIB, and thereby inhibiting preinitiation complex assembly. NC2 is also required for expression of many yeast genes...

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Identifiers

PMID: 12237409
DOI: 10.1073/pnas.202236699
PMCID: PMC130528

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP).PMID 12237409Read ↗

The dual control of TFIIB recruitment by NC2 is gene specific.Semantic proximity Read ↗

Specific defects in different transcription complexes compensate for the requirement of the negative cofactor 2 repressor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interplay of TBP inhibitors in global transcriptional control.Semantic proximity Read ↗

A basal transcription factor that activates or represses transcription.Semantic proximity Read ↗

NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.Semantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

The TBP-TFIIA interaction in the response to acidic activators in vivo.Semantic proximity Read ↗

The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates.Semantic proximity Read ↗

The Drosophila TATA binding protein contains a strong but masked activation domain.Semantic proximity Read ↗

Characterization of Transcription from TATA-Less Promoters: Identification of a New Core Promoter Element XCPE2 and Analysis of Factor RequirementsSemantic proximity Read ↗

The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo.Semantic proximity Read ↗

CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Semantic proximity Read ↗

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