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Article

TATA-binding protein mutants that increase transcription from enhancerless and repressed promoters in vivo.

Molecular and cellular biology - 1 Mar 2000

Geisberg J V, Struhl K

Abstract excerpt

Using a genetic screen, we isolated three TATA-binding protein (TBP) mutants that increase transcription from promoters that are repressed by the Cyc8-Tup1 or Sin3-Rpd3 corepressors or that lack an enhancer element, but not from an equivalently weak promoter with a mutated TATA element. Increased transcription is observed when the TBP mutants are expressed at low levels in the presence of wild-type TBP. These TBP...

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Share to DNA-Binding Proteins
Share to Enhancer Elements, Genetic
Share to Promoter Regions, Genetic

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Share to TATA Box

Share to TATA-Box Binding Protein

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Source

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Identifiers

PMID: 10669725
DOI: 10.1128/MCB.20.5.1478-1488.2000
PMCID: PMC85312

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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