Article
Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.
Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995
Dunbar D R, Moonie P A, Jacobs H T, Holt I J
Abstract excerpt
After the introduction of mitochondria with a mixture of mutant and wild-type mitochondrial DNA (mtDNA) into a human rho degree cell line (143B.206), Yoneda et al. [Yoneda, M., Chomyn, A., Martinuzzi, A., Hurko, O. & Attardi, G. (1992) Proc. Natl. Acad. Sci. USA 89, 11164-11168] observed a shift in the proportion of the two mitochondrial genotypes in a number of cybrid clones. In every case where a shift was...
Topics
- Base Sequence
- Cell Line
- Cells, Cultured
- DNA Primers
- DNA, Mitochondrial
- Genome, Human
- Humans
- Mitochondria, Muscle
- Mitochondrial Myopathies
- Molecular Sequence Data
- Muscles