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Article

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 1995

Dunbar D R, Moonie P A, Jacobs H T, Holt I J

Abstract excerpt

After the introduction of mitochondria with a mixture of mutant and wild-type mitochondrial DNA (mtDNA) into a human rho degree cell line (143B.206), Yoneda et al. [Yoneda, M., Chomyn, A., Martinuzzi, A., Hurko, O. & Attardi, G. (1992) Proc. Natl. Acad. Sci. USA 89, 11164-11168] observed a shift in the proportion of the two mitochondrial genotypes in a number of cybrid clones. In every case where a shift was...

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Identifiers

PMID: 7604033
DOI: 10.1073/pnas.92.14.6562
PMCID: PMC41558

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Source receipt: pubmed, retrieved 7 Sept 2026.

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