Human cell mutants with very low mitochondrial DNA copy number (rho d).

doi:10.1093/hmg/4.5.903

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Article

Human cell mutants with very low mitochondrial DNA copy number (rho d).

Human molecular genetics - 1 May 1995

Vaillant F, Nagley P

Abstract excerpt

Mutants of human Namalwa cells are described, denoted rho d (mtDNA-depleted), which contain a very low mtDNA copy number. Three isolates, denoted FV02, FV03 and FV05, each selected on the basis of their pyruvate-dependent phenotype, were shown to have severely reduced mitochondrial respiratory fu...

Topics

Cell Division
Cell Line
Cytochromes
DNA, Mitochondrial
Genome, Human
Histocytochemistry
Humans
Mitochondria
Multigene Family
Mutation
Oxygen Consumption
Phenotype
Polymerase Chain Reaction
Pyruvates
Pyruvic Acid
Spectrophotometry

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