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Article

Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.

Genetics - 1 Aug 2005

Turner Carrie J, Granycome Caroline, Hurst Rachel, Pohler Elizabeth, Juhola M Katariina, Juhola Martti I, Jacobs Howard T, Sutherland Lesley, Holt Ian J

Abstract excerpt

In this study a well-characterized pathological mutation at nucleotide position 3243 of human mitochondrial DNA was introduced into human rho(0) teratocarcinoma (NT2) cells. In cloned and mixed populations of NT2 cells heteroplasmic for the mutation, mitotic segregation toward increasing levels of mutant mitochondrial DNA always occurred. Rapid segregation was frequently followed by complete loss of mitochondrial...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15944344
DOI: 10.1534/genetics.105.043653
PMCID: PMC1449769

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Source receipt: pubmed, retrieved 7 Sept 2026.

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