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Article

Enhanced tumorigenicity by mitochondrial DNA mild mutations.

Oncotarget - 30 May 2015

Cruz-Bermúdez Alberto, Vallejo Carmen G, Vicente-Blanco Ramiro J, Gallardo María Esther, Fernández-Moreno Miguel Ángel, Quintanilla Miguel, Garesse Rafael

Abstract excerpt

To understand how mitochondria are involved in malignant transformation we have generated a collection of transmitochondrial cybrid cell lines on the same nuclear background (143B) but with mutant mitochondrial DNA (mtDNA) variants with different degrees of pathogenicity. These include the severe mutation in the tRNALys gene, m.8363G>A, and the three milder yet prevalent Leber's hereditary optic neuropathy (LHON)...

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Identifiers

PMID: 25909222
DOI: 10.18632/oncotarget.3698
PMCID: PMC4537038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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