Article
Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function.
Biochemical and biophysical research communications - 12 Jan 2001
Aomi Y, Chen C S, Nakada K, Ito S, Isobe K, Murakami H, Kuno S Y, Tawata M, Matsuoka R, Mizusawa H, Hayashi J I
Abstract excerpt
For determination of whether platelet mtDNA in patients with Parkinson's disease (PD) possesses some lesions to reduce respiratory enzyme activities, platelet mtDNA was transferred into mtDNA-less (rho0) HeLa cells from aged PD patients and age-matched normal subjects, since their activities were controlled by both mitochondrial and nuclear genomes. The resultant mtDNA-repopulated cybrid clones containing the...
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