Heteroplasmic mitochondrial tRNA(Lys) mutation and its complementation in MERRF patient-derived mitochondrial transformants.

doi:10.1002/mus.880181420

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Article

Heteroplasmic mitochondrial tRNA(Lys) mutation and its complementation in MERRF patient-derived mitochondrial transformants.

Muscle & nerve. Supplement - 1 Jan 1995

Yoneda M, Miyatake T, Attardi G

Abstract excerpt

The heteroplasmic tRNA(Lys) mutation in the mitochondrial DNA (mtDNA) is responsible for the phenotypic expression and the transmission of MERRF syndrome. However, the genetic behaviors of the mutant and wild-type mtDNA molecules within a cell are still unknown. We demonstrated a clear genetic co...

Topics

Chloramphenicol
DNA, Mitochondrial
Genetic Complementation Test
Humans
MELAS Syndrome
MERRF Syndrome
Mutation
RNA, Transfer, Lys

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