Transmitochondrial cybrids: tools for functional studies of mutant mitochondria.

doi:10.1007/978-1-61779-504-6_15

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Article

Transmitochondrial cybrids: tools for functional studies of mutant mitochondria.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Vithayathil Sajna Antony, Ma Yewei, Kaipparettu Benny Abraham

Abstract excerpt

Mitochondrial functions are controlled by both mitochondrial DNA (mtDNA) and nuclear DNA. Hence, it is difficult to identify whether mitochondrial or nuclear genome is responsible for a particular mitochondrial defect. Cybrid is a useful tool to overcome this difficulty, where we can compare mitochondria from different sources in a defined nuclear background. Cybrids are constructed by fusing enucleated cells...

Topics

Cell Fusion
DNA, Mitochondrial
Ethidium
Genetic Markers
Humans
Mitochondria
Mutation
Transfection
Uridine

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Open in PubMed

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PMID: 22215551
DOI: 10.1007/978-1-61779-504-6_15

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