Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.

Article

Kinetics of acetyl CoA: arylamine N-acetyltransferase from rapid and slow acetylator human liver.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Kilbane A J, Petroff T, Weber W W

Abstract excerpt

Michaelis-Menten kinetic constants for sulfamethazine (SMZ) and p-aminobenzoic acid (PABA) metabolism were determined in 2 very rapid, 8 intermediate, and 10 slow acetylator human livers. The mean apparent KM values for the monomorphic substrate PABA were 70 +/- 20, 180 +/- 50, and 310 +/- 30 mic...

Topics

4-Aminobenzoic Acid
Acetylation
Arylamine N-Acetyltransferase
Humans
Indicators and Reagents
Kinetics
Liver
Phenotype
Polymorphism, Genetic
Sulfamethoxazole

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