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Article

The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.

Alcohol (Fayetteville, N.Y.) - 1 Nov 2011

Kontturi Leena-Stiina, Aalto Asko J, Wallner Martin, Uusi-Oukari Mikko

Abstract excerpt

The alcohol-tolerant AT and alcohol-nontolerant ANT rat lines have been selectively bred for innate sensitivity to ethanol-induced motor impairment. The cerebellar GABAA receptor (GABAAR) α6 subunit alleles α6-100R and α6-100Q are segregated in the AT and ANT rats, respectively. This α6 polymorphism might explain various differences in pharmacological properties and density of GABAARs between the rat lines. In...

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Identifiers

PMID: 21163615
DOI: 10.1016/j.alcohol.2010.11.003
PMCID: PMC3137752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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