Article
Characterization of wild-type (R100R) and mutated (Q100Q) GABAA alpha 6 subunit in Sardinian alcohol non-preferring rats (sNP).
Brain research - 28 Mar 2003
Sanna Angela, Congeddu Elena, Porcella Anna, Saba Luisella, Pistis Marco, Peis Michela, Marchese Giorgio, Ruiu Stefania, Lobina Carla, Grayson Dennis R, Gessa Gian Luigi, Pani Luca
Abstract excerpt
Sardinian alcohol non-preferring (sNP) rats, selected for their low ethanol preference and consumption, carry a point mutation (R100Q) in the gene coding for GABA(A) receptor alpha(6) subunit, which becomes more sensitive to diazepam-evoked GABA currents. We performed binding studies in the cerebellum of normal (RR) and mutated (QQ) sNP rats using [3H]Ro 15-4513, an inverse agonist for the benzodiazepine site...
Topics
- Alcohol Drinking
- Animals
- Brain
- Ethanol
- Female
- GABA-A Receptor Agonists
- Mutation
- Protein Subunits
- Rats
- Rats, Mutant Strains
- Receptors, GABA-A
- Xenopus laevis