Article
A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2016
Behlke Lauren M, Foster Rachel A, Liu Jing, Benke Dietmar, Benham Rebecca S, Nathanson Anna J, Yee Benjamin K, Zeilhofer Hanns Ulrich, Engin Elif, Rudolph Uwe
Abstract excerpt
Benzodiazepines have been widely used for their anxiolytic actions. However, the contribution of GABAA receptor subtypes to anxiolysis is still controversial. Studies with mutant mice harboring diazepam-insensitive α-subunits α1, α2, α3, or α5 have revealed that α2-containing GABAA receptors (α2-GABAARs) are required for diazepam-induced anxiolysis, with no evidence for an involvement of any other α-subunit,...
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