Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity.

Article

Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity.

Proceedings of the National Science Council, Republic of China. Part B, Life sciences - 1 Jul 1993

Chao Y C, Liou S R, Tsai S F, Yin S J

Abstract excerpt

About half of Chinese individuals lack mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, which is responsible for the oxidation of acetaldehyde produced during ethanol metabolism. The ALDH2 deficiency in Chinese has been implicated in alcohol flush reaction and reported to be a negative ri...

Topics

Aldehyde Dehydrogenase
Alleles
Asian People
Duodenal Ulcer
Gene Expression
Genotype
Humans
Macromolecular Substances
Mutation
Stomach
Stomach Ulcer
Taiwan

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.