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Article

Transformation of human kidney proximal tubule cells by a src-containing retrovirus.

Oncogene - 1 Nov 1991

Nanus D M, Lynch S A, Rao P H, Anderson S M, Jhanwar S C, Albino A P

Abstract excerpt

Analysis of the cell-surface antigenic phenotypes of normal and malignant renal cells demonstrates that approximately 90% of cultured normal human kidney cells and virtually all renal cell carcinomas (RCC) derive from the proximal tubule (PT) cell of the nephron. In the present study, the v-src oncogene was introduced into cultured normal human PT cells, and the effects of the v-src-encoded protein (pp60v-src) on...

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PMID: 1945415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transformation of human kidney proximal tubule cells by a src-containing retrovirus.PMID 1945415Read ↗

Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Semantic proximity Read ↗

Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control.Semantic proximity Read ↗

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.Semantic proximity Read ↗

pp60c-src is required for the induction of a quiescent mesangial cell phenotype.Semantic proximity Read ↗

Contribution of the Src family of kinases to the appearance of malignant phenotypes in renal cancer cells.Semantic proximity Read ↗

Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles.Semantic proximity Read ↗

Functional dissection of transformation by c‐Src and v‐SrcSemantic proximity Read ↗

Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesisSemantic proximity Read ↗

Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src.Semantic proximity Read ↗

SRC in human carcinogenesis.Semantic proximity Read ↗

pp60c-src binding to polyomavirus middle T-antigen (MT) requires residues 185 to 210 of the MT sequence.Semantic proximity Read ↗

Functions of the v-Src protein tyrosine kinase.Semantic proximity Read ↗

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