Article
Transformation of human kidney proximal tubule cells by a src-containing retrovirus.
Oncogene - 1 Nov 1991
Nanus D M, Lynch S A, Rao P H, Anderson S M, Jhanwar S C, Albino A P
Abstract excerpt
Analysis of the cell-surface antigenic phenotypes of normal and malignant renal cells demonstrates that approximately 90% of cultured normal human kidney cells and virtually all renal cell carcinomas (RCC) derive from the proximal tubule (PT) cell of the nephron. In the present study, the v-src oncogene was introduced into cultured normal human PT cells, and the effects of the v-src-encoded protein (pp60v-src) on...
Topics
- Animals
- Blotting, Southern
- Carcinoma, Renal Cell
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromosome Banding
- Chromosomes, Human, Pair 3
- Female
- Genes, src
- Humans
- Immunoenzyme Techniques