Article
Src kinase contributes to the metastatic spread of carcinoma cells.
Oncogene - 4 Apr 2002
Boyer Brigitte, Bourgeois Yveline, Poupon Marie-France
Abstract excerpt
The involvement of Src kinase during carcinoma metastasis has been explored by using the NBT-II rat carcinoma cell line, which can be induced to scatter in vitro through Src activity. Here we show that Src activity was not required for growth of tumors derived from NBT-II cells injected into nude mice. In contrast, the presence of micrometastases was strictly dependent on Src, since the percentage of mice bearing...
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