Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.

Journal of cell science - 15 Jun 2002

Edme Natacha, Downward Julian, Thiery Jean-Paul, Boyer Brigitte

Abstract excerpt

Cell dissociation and cell migration are the two main components of epithelium-mesenchyme transitions (EMT). We previously demonstrated that Ras is required for the accomplishment of both of these processes during the EGF-induced EMT of the NBT-II rat carcinoma cell line in vitro. In this study, we examined the downstream targets of Ras that are responsible for the dissociation and motility of NBT-II cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Desmosomes
Share to Endocytosis
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to MAP Kinase Kinase 1

Share to Mesoderm

Share to Mitogen-Activated Protein Kinase Kinases

Share to rac GTP-Binding Proteins

Source

Identifiers

PMID: 12045229
DOI: 10.1242/jcs.115.12.2591

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras induces NBT-II epithelial cell scattering through the coordinate activities of Rac and MAPK pathways.PMID 12045229Read ↗

Non-cell-autonomous migration of RasV12-transformed cells towards the basal side of surrounding normal cells.Semantic proximity Read ↗

Ras alters epithelial-mesenchymal transition in response to TGF-β by reducing actin fibers and cell-matrix adhesionSemantic proximity Read ↗

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.Semantic proximity Read ↗

RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.Semantic proximity Read ↗

pp60c-src is a positive regulator of growth factor-induced cell scattering in a rat bladder carcinoma cell line.Semantic proximity Read ↗

Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes.Semantic proximity Read ↗

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition.Semantic proximity Read ↗

FilGAP, a Rho/Rho-associated protein kinase-regulated GTPase-activating protein for Rac, controls tumor cell migration.Semantic proximity Read ↗

Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53.Semantic proximity Read ↗

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.Semantic proximity Read ↗

Identification of protein kinase C as an intermediate in Na,K-ATPase beta-subunit mediated lamellipodia formation and suppression of cell motility in carcinoma cells.Semantic proximity Read ↗

The Rb tumor suppressor regulates epithelial cell migration and polarity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.