Article
The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.
The Journal of biological chemistry - 27 Oct 1995
Koromilas A E, Cantin C, Craig A W, Jagus R, Hiscott J, Sonenberg N
Abstract excerpt
PKR is an interferon (IFN)-induced serine/threonine protein kinase that regulates protein synthesis through phosphorylation of eukaryotic translation initiation factor-2 (eIF-2). In addition to its demonstrated role in translational control, recent findings suggest that PKR plays an important rol...
Topics
- Animals
- Base Sequence
- Enzyme Induction
- Eukaryotic Initiation Factor-2
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Neoplastic
- Genes, Immunoglobulin
- Humans
- Immunoglobulin M
- Immunoglobulin kappa-Chains
- Lymphoma, B-Cell
- Mice
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Phosphorylation
- Precancerous Conditions
- Protein Serine-Threonine Kinases