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Article

The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.

The Journal of biological chemistry - 27 Oct 1995

Koromilas A E, Cantin C, Craig A W, Jagus R, Hiscott J, Sonenberg N

Abstract excerpt

PKR is an interferon (IFN)-induced serine/threonine protein kinase that regulates protein synthesis through phosphorylation of eukaryotic translation initiation factor-2 (eIF-2). In addition to its demonstrated role in translational control, recent findings suggest that PKR plays an important role in regulation of gene transcription, as PKR phosphorylates I kappa B alpha upon double-stranded RNA treatment...

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Source

Identifiers

PMID: 7592710
DOI: 10.1074/jbc.270.43.25426

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.PMID 7592710Read ↗

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.Semantic proximity Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis.Semantic proximity Read ↗

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.Semantic proximity Read ↗

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.Semantic proximity Read ↗

The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.Semantic proximity Read ↗

IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.Semantic proximity Read ↗

Engagement of protein kinase C-theta in interferon signaling in T-cells.Semantic proximity Read ↗

Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.Semantic proximity Read ↗

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