The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.

doi:10.1006/excr.1998.4201

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Article

The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.

Experimental cell research - 1 Nov 1998

Abraham N, Jaramillo M L, Duncan P I, Méthot N, Icely P L, Stojdl D F, Barber G N, Bell J C

Abstract excerpt

The double-stranded RNA-dependent kinase, PKR, is encoded by an interferon inducible gene and is largely responsible for the anti-viral effects of this cytokine. Recent studies have shown that PKR may also play a role in the regulation of normal cellular growth. Although numerous examples of vira...

Topics

Alleles
Animals
COS Cells
Cell Line
Dimerization
Eukaryotic Initiation Factor-2
Genes, Tumor Suppressor
Humans
Leukemia L1210
Leukemia, Lymphoid
Mice
Phosphorylation
Sequence Deletion
Sequence Homology, Amino Acid
eIF-2 Kinase

Source

Open in PubMed

Identifiers

PMID: 9806790
DOI: 10.1006/excr.1998.4201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9806790-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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