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Article

The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.

Experimental cell research - 1 Nov 1998

Abraham N, Jaramillo M L, Duncan P I, Méthot N, Icely P L, Stojdl D F, Barber G N, Bell J C

Abstract excerpt

The double-stranded RNA-dependent kinase, PKR, is encoded by an interferon inducible gene and is largely responsible for the anti-viral effects of this cytokine. Recent studies have shown that PKR may also play a role in the regulation of normal cellular growth. Although numerous examples of viral strategies for inactivation of PKR exist, there is no evidence of PKR inactivation in tumors. We demonstrate here...

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Source

Identifiers

PMID: 9806790
DOI: 10.1006/excr.1998.4201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia.PMID 9806790Read ↗

Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.Semantic proximity Read ↗

Identification of functional domains of the interferon-induced enzyme PKR in cells lacking endogenous PKR.Semantic proximity Read ↗

Expression of human PKR protein kinase in transgenic mice.Semantic proximity Read ↗

Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity.Semantic proximity Read ↗

Identification of the interferon-inducible double-stranded RNA-dependent protein kinase as a regulator of cellular response to bulky adducts.Semantic proximity Read ↗

The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.Semantic proximity Read ↗

Functional characterization of pkr gene products expressed in cells from mice with a targeted deletion of the N terminus or C terminus domain of PKR.Semantic proximity Read ↗

Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein KinaseSemantic proximity Read ↗

Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.Semantic proximity Read ↗

Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Semantic proximity Read ↗

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.Semantic proximity Read ↗

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