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Article

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.

The EMBO journal - 15 Aug 2000

Goh K C, deVeer M J, Williams B R

Abstract excerpt

Protein kinase RNA-regulated (PKR) is an established component of innate antiviral immunity. Recently, PKR has been shown to be essential for signal transduction in other situations of cellular stress. The relationship between PKR and the stress-activated protein kinases (SAPKs), such as p38 mitogen-activated protein kinase (MAPK), is not clear. Using embryonic fibroblasts from PKR wild-type and null mice, we...

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Identifiers

PMID: 10944112
DOI: 10.1093/emboj/19.16.4292
PMCID: PMC302024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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