Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis.

doi:10.1074/jbc.M511983200

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Article

Human gene profiling in response to the active protein kinase, interferon-induced serine/threonine protein kinase (PKR), in infected cells. Involvement of the transcription factor ATF-3 IN PKR-induced apoptosis.

The Journal of biological chemistry - 7 Jul 2006

Guerra Susana, López-Fernández Luis A, García María Angel, Zaballos Angel, Esteban Mariano

Abstract excerpt

The interferon-induced serine/threonine protein kinase (PKR) has an essential role in cell survival and cell death after viral infection and under stress conditions, but the host genes involved in these processes are not well defined. We used human cDNA microarrays to identify, in infected cells, genes differentially expressed after PKR expression and analyzed the requirement of catalytic activity of the enzyme....

Topics

3T3 Cells
Activating Transcription Factor 3
Animals
Apoptosis
Catalysis
Gene Expression Profiling
Gene Expression Regulation, Enzymologic
HeLa Cells
Humans
Interferons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Recombinant Proteins

Vaccinia

Vaccinia virus

eIF-2 Kinase

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Open in PubMed

Identifiers

PMID: 16613840
DOI: 10.1074/jbc.M511983200

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