Article
Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1998
Kawakami Y, Robbins P F, Wang X, Tupesis J P, Parkhurst M R, Kang X, Sakaguchi K, Appella E, Rosenberg S A
Abstract excerpt
To isolate melanoma Ags recognized by T cells, cDNA libraries made from melanoma cell lines were screened with four CTLs derived from tumor infiltrating lymphocytes (TIL) that were able to recognize melanoma cells in a HLA-A1, -A2, or -A3 restricted manner. Although cDNAs encoding the previously identified melanoma Ags, tyrosinase and gp100, were isolated, these TIL were found to recognize previously unidentified...
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