Specific targeting of a mutant, activated FGF receptor found in glioblastoma using a monoclonal antibody.

doi:10.1002/ijc.2910630414

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Specific targeting of a mutant, activated FGF receptor found in glioblastoma using a monoclonal antibody.

International journal of cancer - 15 Nov 1995

Hills D, Rowlinson-Busza G, Gullick W J

Abstract excerpt

A truncated epidermal growth factor receptor (EGFR) expressed from a rearranged and amplified EGFR gene is present at high frequency in gliomas. In this work we show that when this receptor is expressed in NIH3T3 fibroblasts it is partially activated and confers tumorigenicity to this cell line in vivo but no growth advantage in in vitro anchorage-independent growth assays. Because the mutation occurs in the...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Antibodies, Monoclonal
Antibody Specificity
Base Sequence
Cell Transformation, Neoplastic
Epitopes
ErbB Receptors
Glioblastoma
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Nude

Molecular Sequence Data

Mutation

Neoplasm Transplantation

Phosphorylation

Rabbits

Source

Open in PubMed

Identifiers

PMID: 7591264
DOI: 10.1002/ijc.2910630414

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7591264-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific targeting of a mutant, activated FGF receptor found in glioblastoma using a monoclonal antibody.PMID 7591264Read ↗

Mutant epidermal growth factor receptors as targets for cancer therapy.Semantic proximity Read ↗

Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.Semantic proximity Read ↗

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.Semantic proximity Read ↗

Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.Semantic proximity Read ↗

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.Semantic proximity Read ↗

Development of an EGFRvIII specific recombinant antibodySemantic proximity Read ↗

Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.Semantic proximity Read ↗

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.Semantic proximity Read ↗

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.Semantic proximity Read ↗

Structural alterations of the epidermal growth factor receptor gene in human gliomas.Semantic proximity Read ↗

Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma.Semantic proximity Read ↗

Selective interaction of a conformationally-constrained Arg-Gly-Asp (RGD) motif with the integrin receptor alphavbeta3 expressed on human tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.