Article
Antibody recognition of a conformational epitope in a peptide antigen: Fv-peptide complex of an antibody fragment specific for the mutant EGF receptor, EGFRvIII.
Journal of molecular biology - 18 May 2001
Landry R C, Klimowicz A C, Lavictoire S J, Borisova S, Kottachchi D T, Lorimer I A, Evans S V
Abstract excerpt
Epitope mapping studies and the determination of the structure to 1.8 A resolution have been carried out for the antigen-binding fragment MR1 in complex with peptide antigen. MR1 is specific for the novel fusion junction of the mutant epidermal growth factor receptor EGFRvIII and has been reported to have a high degree of specificity for the mutant EGFRvIII over the wild-type EGF receptor. The structure of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.