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Development of an EGFRvIII specific recombinant antibody

7 Oct 2010

Abstract excerpt

BACKGROUND: EGF receptor variant III (EGFRvIII) is the most common variant of the EGF receptor observed in human tumors. It results from the in frame deletion of exons 2-7 and the generation of a novel glycine residue at the junction of exons 1 and 8. This novel juxtaposition of amino acids within the extra-cellular domain of the EGF receptor creates a tumor specific and immunogenic epitope. EGFRvIII expression...

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PMID: 20925961
DOI: 10.1186/1472-6750-10-72

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