Article
Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor.
The Journal of biological chemistry - 16 Jul 2004
Johns Terrance G, Adams Timothy E, Cochran Jennifer R, Hall Nathan E, Hoyne Peter A, Olsen Mark J, Kim Yong-Sung, Rothacker Julie, Nice Edouard C, Walker Francesca, Ritter Gerd, Jungbluth Achim A, Old Lloyd J, Ward Colin W, Burgess Antony W, Wittrup K Dane, Scott Andrew M
Abstract excerpt
The epidermal growth factor receptor (EGFR) is overexpressed in many epithelial cancers, an observation often correlated with poor clinical outcome. Overexpression of the EGFR is commonly caused by EGFR gene amplification and is sometimes associated with expression of a variant EGFR (de2-7 EGFR or EGFRvIII) bearing an internal deletion in its extracellular domain. Monoclonal antibody (mAb) 806 is a novel EGFR...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.