Article
A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A.
Genomics - 1 Jul 1995
Mazoyer S, Gayther S A, Nagai M A, Smith S A, Dunning A, van Rensburg E J, Albertsen H, White R, Ponder B A
Abstract excerpt
We have isolated a novel cDNA that maps distal to BRCA1 at 17q12-q21. The total sequence predicts a protein of 576 amino acids with three conserved regions: a 90-amino-acid repeat domain, a SH3 (src homology region 3) motif, and a guanylate kinase domain. These conserved regions are shared among members of the discs-large family of proteins that include human p55, a membrane protein expressed in erythrocytes, rat...
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