A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A.

doi:10.1006/geno.1995.1101

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Article

A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A.

Genomics - 1 Jul 1995

Mazoyer S, Gayther S A, Nagai M A, Smith S A, Dunning A, van Rensburg E J, Albertsen H, White R, Ponder B A

Abstract excerpt

We have isolated a novel cDNA that maps distal to BRCA1 at 17q12-q21. The total sequence predicts a protein of 576 amino acids with three conserved regions: a 90-amino-acid repeat domain, a SH3 (src homology region 3) motif, and a guanylate kinase domain. These conserved regions are shared among members of the discs-large family of proteins that include human p55, a membrane protein expressed in erythrocytes, rat...

Topics

Amino Acid Sequence
Animals
Base Sequence
Breast Neoplasms
Dogs
Drosophila
Drosophila Proteins
Female
Gene Rearrangement
Genes, Tumor Suppressor
Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insect Hormones

Mice

Molecular Sequence Data

Mutation

Ovarian Neoplasms

Rats

Source

Open in PubMed

Identifiers

PMID: 7590743
DOI: 10.1006/geno.1995.1101

Genes

DLG2
BRCA1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7590743-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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