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Article

Mutation analysis of the gene encoding the PALB2-binding protein MRG15 in BRCA1/2-negative breast cancer families.

Journal of human genetics - 1 Dec 2010

Rio Frio Thomas, Haanpää Maria, Pouchet Carly, Pylkäs Katri, Vuorela Mikko, Tischkowitz Marc, Winqvist Robert, Foulkes William D

Abstract excerpt

MRG15 is a recently identified member of the BRCA multiprotein complex, essential for the maintenance of the genome integrity and DNA repair. The functional relationship between PALB2 and MRG15 makes MRG15 a strong candidate breast cancer susceptibility gene. We screened affected probands from 232 BRCA1/2-negative breast cancer families for mutations in MRG15. We identified seven previously unreported variants...

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Source

Identifiers

PMID: 20844547
DOI: 10.1038/jhg.2010.112

Genes

BRCA1
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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