Article

Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3

2019-02-14

Abstract excerpt

<h4>Objective</h4> Proteinase 3 (PR3) is the major antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) in the systemic autoimmune vasculitis, granulomatosis with polyangiitis (GPA). PR3 anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) recognize different epitopes on PR3. We aimed to study the effect of mutations on PR3 antigenicity. <h4>Methods</h4> The recombinant PR3 variants, iPR3 which is clinically...

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Literature Corpus work: 9da8fc6b-02b9-5490-8b9a-215f852e99b2
DOI: 10.1101/549063

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