Exploration of the metabolism of dihydrocodeine via determination of its metabolites in human urine using micellar electrokinetic capillary chromatography.

doi:10.1016/0378-4347(95)00046-l

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Article

Exploration of the metabolism of dihydrocodeine via determination of its metabolites in human urine using micellar electrokinetic capillary chromatography.

Journal of chromatography. B, Biomedical applications - 9 Jun 1995

Hufschmid E, Theurillat R, Martin U, Thormann W

Abstract excerpt

After single-dose administration of 40 or 60 mg of dihydrocodeine (DHC, in a slow-release tablet) to four healthy individuals known to be extensive metabolizers of debrisoquine, the urinary excretion of DHC and its four major metabolites, dihydrocodeine-6-glucuronide, nordihydrocodeine, dihydromo...

Topics

Chromatography, Liquid
Codeine
Drug Interactions
Electrochemistry
Humans
Hydrolysis
Phenotype
Premedication
Quinidine
Reference Values

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