A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

doi:10.1111/j.1365-2125.1991.tb05586.x

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Article

A comparison of the pharmacokinetics of codeine and its metabolites in healthy Chinese and Caucasian extensive hydroxylators of debrisoquine.

British journal of clinical pharmacology - 1 Jun 1991

Yue Q Y, Svensson J O, Sjöqvist F, Säwe J

Abstract excerpt

1. The kinetics of codeine and metabolites were studied in eight unrelated healthy Chinese subjects following a single oral dose of 50 mg codeine phosphate. The data were compared with those from eight Caucasian subjects who were matched with the Chinese group according to their metabolic ratio (...

Topics

Administration, Oral
Adult
Asian People
Chromatography, High Pressure Liquid
Codeine
Debrisoquin
Female
Humans
Male
Middle Aged
Phenotype
Reference Values
White People

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