Article
Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells.
Nucleic acids research - 1 Mar 1998
Le Page F, Guy A, Cadet J, Sarasin A, Gentil A
Abstract excerpt
Replication of the oxidative lesion 8-oxo-7,8-dihydroguanine (GO) leads to the formation of both 8-oxo-7,8-dihydroguanine:adenine (GO:A) and 8-oxo-7,8-di-hydroguanine:cytosine (GO:C) pairs. The repair and mutagenic potency of these two kinds of base pairs were studied in simian COS7 and human MRC...
Topics
- Animals
- Base Composition
- Base Sequence
- COS Cells
- Cell Line
- Chlorocebus aethiops
- DNA Repair
- DNA Replication
- Escherichia coli
- Genetic Vectors
- Guanine
- Humans
- Kinetics
- Mutation
- Plasmids
- Transfection