Mapping of (+/-)-anti-benzo[a]pyrene diol epoxide adducts to human c-Ha-ras1 protooncogene.

doi:10.1021/tx00021a003

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Article

Mapping of (+/-)-anti-benzo[a]pyrene diol epoxide adducts to human c-Ha-ras1 protooncogene.

Chemical research in toxicology - 1 Jan 2000

Dittrich K A, Krugh T R

Abstract excerpt

The relative reactivity of the chemical carcinogen (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+/-)-anti-BPDE] to the guanine bases of the first two coding exons of the human c-Ha-ras1 protooncogene is determined to test if (+/-)-anti-BPDE reactivity...

Topics

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Base Sequence
Binding Sites
Chromosome Mapping
Codon
DNA
Exons
Gene Expression Regulation
Genes, ras
Guanine
Humans
Molecular Sequence Data
Mutation
Photochemistry
Proto-Oncogenes

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