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Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment

7 Sept 2015

Abstract excerpt

In many organs, including the intestine and skin, cancers originate from cells of the stem or progenitor compartment. Despite its nomenclature, the cellular origin of hepatocellular carcinoma (HCC) remains elusive. In contrast to most organs, the liver lacks a defined stem cell population for organ maintenance. Previous studies suggest that both hepatocytes and facultative progenitor cells within the biliary...

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Share to Hepatocellular Carcinoma Treatment and Prognosis
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PMID: 26348897
DOI: 10.1172/jci77995

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