Article
Specificity of Prp24 binding to RNA: a role for Prp24 in the dynamic interaction of U4 and U6 snRNAs.
RNA (New York, N.Y.) - 1 Apr 1995
Ghetti A, Company M, Abelson J
Abstract excerpt
Prp24 was previously isolated as a suppressor of a cold-sensitive U4 mutation and is required for at least the first step of splicing in vitro. Our investigation of the in vitro RNA binding properties of the purified Prp24 protein shows that it binds preferentially to the U4/U6 hybrid snRNAs comp...
Topics
- Base Sequence
- Hydroxyl Radical
- Ligands
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- RNA
- RNA Splicing
- RNA, Small Nuclear
- RNA-Binding Proteins
- Repressor Proteins
- Ribonucleoprotein, U4-U6 Small Nuclear
- Spliceosomes
- Structure-Activity Relationship
- Temperature