Article
Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.
Journal of molecular biology - 13 Apr 2007
Bae Euiyoung, Reiter Nicholas J, Bingman Craig A, Kwan Sharon S, Lee Donghan, Phillips George N, Butcher Samuel E, Brow David A
Abstract excerpt
The essential Saccharomyces cerevisiae pre-messenger RNA splicing protein 24 (Prp24) has four RNA recognition motifs (RRMs) and facilitates U6 RNA base-pairing with U4 RNA during spliceosome assembly. Prp24 is a component of the free U6 small nuclear ribonucleoprotein particle (snRNP) but not the U4/U6 bi-snRNP, and so is thought to be displaced from U6 by U4/U6 base-pairing. The interaction partners of each of...
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