Article
G-->A substitution at position -75 of the apolipoprotein A-I gene promoter. Evidence against a direct effect on HDL cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1995
Minnich A, DeLangavant G, Lavigne J, Roederer G, Lussier-Cacan S, Davignon J
Abstract excerpt
The present study sought to resolve the contradictory evidence as to whether the G-->A substitution at position -75 of the apoA-I gene promoter raises HDL cholesterol (HDL-C) levels by examining the effect of this polymorphism in French Canadians, a relatively genetically homogeneous population. Among 308 women, carriers of the A allele displayed 12% and 10% higher mean plasma HDL-C and apoA-I concentrations,...
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