Article
G-->A substitution at position -75 of the apolipoprotein A-I gene promoter. Evidence against a direct effect on HDL cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1995
Minnich A, DeLangavant G, Lavigne J, Roederer G, Lussier-Cacan S, Davignon J
Abstract excerpt
The present study sought to resolve the contradictory evidence as to whether the G-->A substitution at position -75 of the apoA-I gene promoter raises HDL cholesterol (HDL-C) levels by examining the effect of this polymorphism in French Canadians, a relatively genetically homogeneous population....
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Apolipoprotein A-I
- Base Sequence
- Canada
- Cholesterol, HDL
- Female
- Genetic Linkage
- Humans
- Hyperlipoproteinemias
- Male
- Middle Aged
- Molecular Sequence Data
- Pedigree
- Point Mutation