Article
G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations.
Molecular biology & medicine - 1 Jun 1990
Jeenah M, Kessling A, Miller N, Humphries S
Abstract excerpt
We have determined the sequence of 250 bases 5' of the transcriptional start site of the apolipoprotein AI gene in a human individual with high serum concentrations of apo AI. One of the alleles contained a G to A substitution at position -75, between the CACAT sequence and the TAAATA box, creating a tandem repeat, CAGGGC-CA*GGGC. The substitution destroys an MspI cutting site, and the polymerase chain reaction...
Topics
- Alleles
- Apolipoprotein A-I
- Apolipoproteins A
- Base Sequence
- Cholesterol, HDL
- Gene Expression Regulation
- Genes
- Humans
- Lipoproteins, HDL
- Male
- Molecular Sequence Data